![]() The percentage of abnormal cells found will determine whether an embryo is classified as high- or low-level mosaic. However, some abnormal cells may still be mixed in. If a division error occurs later in embryonic development, most cells in the embryo will be chromosomally normal. If an error in division occurs very soon after fertilization, the impact on the embryo can be dramatic. Errors in division that happen further along in embryonic development may result in a lower percentage of mosaicism, while errors that happen when an embryo consists of only a few cells can have a greater impact. It happens when there is an error in the division of cells in the early stages of embryo development.Įmbryonic cells divide extremely rapidly, resulting in the development of a blastocyst just a few days after fertilization. However, embryos with high levels of mosaic cells are less likely to result in a successful pregnancy. Mosaicism doesn’t necessarily mean that an embryo won’t develop normally. When PGT-A results come back, we find that most embryos actually do have some level of mosaicism. It does not touch the inner cell mass, which will become the baby. To get an overall idea of an embryo’s chromosomal makeup, PGT-A tests a small sampling of cells from the outermost layer (trophectoderm) of the embryo. ![]() Mosaicism is a condition in which there is a combination of both normal and abnormal cells within the same embryo. In a small number of embryos, PGT-A identifies a third category of results: mosaicism. ![]() Embryos with extra or missing chromosomes are “aneuploid.” Aneuploid embryos often result in an unsuccessful pregnancy, or they may lead to the birth of a child with a chromosomal abnormality. This information helps you and your fertility specialist select the best embryo for transfer.Įmbryos that contain the correct number and order of chromosomes are “euploid.” Euploid embryos are most likely to result in a successful pregnancy. It can also identify the presence of embryo mosaicism. Preimplantation genetic testing for aneuploidy (PGT-A) provides information about the genetic health of your embryos. We can help you learn more so that you can have peace of mind as you build your family.Understanding embryo mosaicism reported by PGT-A If you still have questions about IVF embryos, contact us to schedule an appointment. Our doctors realize this is a deeply personal decision, so they will provide compassionate support and guidance to help patients make this choice. However, our team may consider transferring a mosaic embryo if the only remaining embryos are abnormal. We will always transfer chromosomally normal embryos before mosaic ones. Should they discard mosaic embryos to avoid potential issues? Or should they transfer one in hopes that it will develop into a healthy baby?īefore deciding, we recommend speaking to our Austin fertility doctors and a genetic counselor. This uncertainty leaves questions in many intended parents’ minds. For example, it could result in implantation failure, miscarriage or a baby with birth defects. However, if the abnormal cells multiply in the embryo, there could be problems. This can also occur if the abnormal cells are only in what will become the placenta. A healthy baby can develop if those abnormal cells die off and the embryo self-corrects. When an embryo divides rapidly after fertilization, mistakes can happen during cell division. Just because an embryo has a mix of normal and abnormal cells, it doesn’t mean that it can’t mature into a healthy baby. ![]() Can mosaic embryos develop into healthy babies? However, this number increases with maternal age because egg quality and quantity decline over time. These embryos contain both normal and abnormal cells, and we know that about 20% of all embryos are mosaic. However, reproductive medicine and testing has come a long way, so we now know that there can be a middle ground in the form of mosaic embryos. ![]() In the past, PGT-A was only precise enough to determine whether an embryo was normal or abnormal. This form of testing allows embryologists to determine whether an embryo is chromosomally normal (euploid) or abnormal (aneuploid). When patients have IVF, they can also order PGT-A for their embryos. What are the different types of IVF embryos? However, it can also raise other questions when there are mosaic embryos. Preimplantation genetic testing for aneuploidy (PGT-A) can shed some light on this topic. Patients often want to know whether their IVF embryos are chromosomally normal or abnormal. We don’t expect you to find the answers yourself, which is why our Austin fertility doctors are here to guide you. When you start to dive into the world of in vitro fertilization (IVF), you’re introduced to new terms and concepts. We’ve got the answers to your questions about mosaic embryos ![]()
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